Discovering new possibilities through science


​​​​​​Structural biologist and BGS 2005 Vice Captain, Eamon Byrne '05 has published his first 'first-author' scientific paper in the prestigious scientific journal Nature.

Currently undertaking doctoral studies at Oxford University, Byrne was part of a 14-person team to produce the paper – Structural basis of Smoothened regulation by its extracellular domains, published in July.

Byrne's work, which involves focusing on the protein machine called Smoothened, is incredibly complex, as evidenced by the first sentence of the Abstract:

Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a heptahelical transmembrane domain (TMD) and an extracellular cysteine-rich domain (CRD).

His studies have uncovered never before discoveries, one of them helping to understand how certain drugs work. The discoveries have the potential to devise better strategies to treat certain types of cancers.

To access the paper click here.

Due to the complexity of the language and work, Byrne has explained the paper in layman's terms on his personal blog​.

It hasn't been all work for Byrne, who recently got engaged to his long term partner Yien Li Yap. The pair met while studying at Melbourne University.